14.4.4 Vasoconstrictor Assay

This approach is used to determine the efficacy and safety of the dermaceuticals and

is also known as skin blanching assay. In this, color of the skin is checked using

Minolta chroma meter (Kanfer 2010). The instrument has a chamber where adhesive

Fig. 14.1 Steps for tape stripping. (a) The application of the formulation on the surface of the skin,

(b) distribution of the formulation, (c) the rolling of adhesive tap using a roller, (d) the removal of

tape (reprinted with permission from Lademann et al. (2009))

Fig. 14.2 Process for

microdialysis (reprinted with

permission from Benfeldt

et al. (2007))

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